Having problems getting your install of The Sims 3 to run? I couldn't find any help on their support page. If your local drive was installed as a different letter than C: , you may have luck running the application directly by double clicking the game executable instead of the launcher.
Found mine installed at:
I:\Program Files (x86)\Electronic Arts\The Sims 3\Game\Bin\TS3.exe
Make a shortcut while you're there